Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment

This is the published version, also available here: http://dx.doi.org/10.1007/s11689-009-9031-x.We analyzed genetic linkage and association of measures of language, speech and reading phenotypes to candidate regions in a single set of families ascertained for SLI. Sib-pair and family-based analyses were carried out for candidate gene loci for Reading Disability (RD) on chromosomes 1p36, 3p12-q13, 6p22, and 15q21, and the speech-language candidate region on 7q31 in a sample of 322 participants ascertained for Specific Language Impairment (SLI). Replication or suggestive replication of linkage was obtained in all of these regions, but the evidence suggests that the genetic influences may not be identical for the three domains. In particular, linkage analysis replicated the influence of genes on chromosome 6p for all three domains, but association analysis indicated that only one of the candidate genes for reading disability, KIAA0319, had a strong effect on language phenotypes. The findings are consistent with a multiple gene model of the comorbidity between language impairments and reading disability and have implications for neurocognitive developmental models and maturational processes

Forest resource information system, phase 3

There are no author-identified significant results in this report

Beyond excise taxes: a systematic review of literature on non-tax policy approaches to raising tobacco product prices

Raising the price of tobacco products is considered one of the most effective ways to reduce tobacco use. In addition to excise taxes, governments are exploring other policies to raise tobacco prices and minimise price dispersion, both within and across price tiers. We conducted a systematic review to determine how these policies are described, recommended and evaluated in the literature

Ursinus College Alumni Journal, Spring 1947

It\u27s time to vote • President\u27s page • News from the campus: Club meetings; Debating; Forum Committee; Curtain Club; YM and YW; Men\u27s sports; Women\u27s sports; New coach appointed; May Day; Alumni Day • Christian education in China • Around town • Ursinus professor honored • Tribute to Dean Kline • News about ourselves • Function of an alumni association • Reunion abroad • Necrology • War Memorial Committee requests expression of opinion from alumni • Alumni Association nomineeshttps://digitalcommons.ursinus.edu/alumnijournal/1030/thumbnail.jp

Ursinus College Alumni Journal, Winter 1946

Dean • President\u27s page • Record enrollment in 76th year • Necrology • Dean Kline dies in 83rd year • Livingood honored • Dr. Niblo attends Episcopal convention • Music room developed • Faculty increased • Revue of sports • Seeders appointed head basketball coach • Student activities • Letters to the alumni • Old Timers\u27 Day • Alumni committees appointed • Re-education of Germany • News about ourselves • Dr. Haines: Teacher and author • News around town • Recipient of Rotary Club award • Dr. Markley completes term of service • 1946 and football • As the placement office sees us • Men\u27s basketball schedulehttps://digitalcommons.ursinus.edu/alumnijournal/1026/thumbnail.jp

Ursinus College Alumni Journal, Winter 1945

Dedication • What kind of memorial? • Alumni Day, 1946 • President\u27s page • Ursinus celebrates 75th anniversary: Special convocation held • Commencement exercises • Opening exercises, 76th academic year • Ursinus College Woman\u27s Club plans many activities • Sports revue • Gold star men of Ursinus • Salutation • Our foreign correspondents • Letter to the alumni • College entertains Navy unit • Returned to civilian status • News about ourselves • Necrology • Alumni Association executive committee creates reserve fund • Specialist in weather forecasting • Honored men of Ursinushttps://digitalcommons.ursinus.edu/alumnijournal/1023/thumbnail.jp

Trapping and Wiggling: Elastohydrodynamics of Driven Microfilaments

We present a general theoretical analysis of semiflexible filaments subject to viscous drag or point forcing. These are the relevant forces in dynamic experiments designed to measure biopolymer bending moduli. By analogy with the ``Stokes problems" in hydrodynamics (fluid motion induced by that of a wall bounding a viscous fluid), we consider the motion of a polymer one end of which is moved in an impulsive or oscillatory way. Analytical solutions for the time-dependent shapes of such moving polymers are obtained within an analysis applicable to small-amplitude deformations. In the case of oscillatory driving, particular attention is paid to a characteristic length determined by the frequency of oscillation, the polymer persistence length, and the viscous drag coefficient. Experiments on actin filaments manipulated with optical traps confirm the scaling law predicted by the analysis and provide a new technique for measuring the elastic bending modulus. A re-analysis of several published experiments on microtubules is also presented.Comment: RevTex, 24 pages, 15 eps figs, uses cite.sty, Biophysical

Ursinus College Alumni Journal, Spring 1946

Farewells to Ursinus • Education for veterans • Alumni Day • President\u27s page • Faculty and staff changes announced • Exhibits to be shown Commencement week • College pastor retires after 18 years\u27 service • Loyalty Fund grows • Professor and Mrs. Sheeder to leave Ursinus • Enrollments remain at high peak • Warren K. Hess \u2731, elected Berks judge • Wounded veterans attend courses • Ursinus and World War II • Store displays mural of college • News from the campus • Athletic policy defined • Sports revue • Secretary\u27s letter • Ensminger \u2714, receives Legion of Merit medal • Former professor invents electronic computer • Control of nuclear energy • News about ourselves • Necrology • Dr. DeWire aided in atom bomb experiments • Alumni Association nomineeshttps://digitalcommons.ursinus.edu/alumnijournal/1027/thumbnail.jp

Ursinus College Alumni Journal, Summer 1946

Board of Directors encourage alumni participation • Alumni committees active • Dr. Johnson commencement speaker • President\u27s page • Directors plan for future • Alumni give $31,000 • Retirement plan • Five earn degrees • Missions secretary • Modern pioneer • Operations Africa • A Dean\u27s mailbox • That others may live • Dr. Miller retires • Seminary gets new head • Faculty and staff additions • Penfield winner • Dr. Garrett studies in France • News about ourselves • Commencement prizes • Challenge of Picalqui • Highlights in fall sports • Local Alumni Association meetings • News around town • Necrology • Summer conferences • College solves housing problem • Fall enrollment 700 • Alumni Association officershttps://digitalcommons.ursinus.edu/alumnijournal/1028/thumbnail.jp

Genome-wide screening for DNA variants associated with reading and language traits

This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant Grant Number: G0900747 91070Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on‐going international efforts to identify genes contributing to reading and language skills.Publisher PDFPeer reviewe